Conference Reports
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IMW Boston 2019[ + ]
Congratulations to the recipients of the UKMF Travel Bursary to the IMW meeting in Boston, September 2019. Thank you to our Platinum Sponsors for jointly awarding these travel bursaries.
- Wei Yee Chan – Binding Site
- Firas Al-Kaisi – Takeda
- Roisin McAvera – Celgene
- Sarah Bird – Amgen
The recipients of the travel grant have written a review of the meeting, which can be found below.
Thank you also to Dr Rachel Hall and Dr Guy Pratt for their review from this meeting. This can also be found in the documents below.
- EHA Review June 2019[ + ]
- ASH 2018 San Diego[ + ]
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EHA Stockholm June 2018[ + ]
We wish to thank Dr Richard Soutar and Dr Guy Pratt for producing a review from EHA Stockholm in June 2018.
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ASH 2017 Atlanta[ + ]
The following reports from ASH Atlanta 2017 were kindly provided by the recipients of the UKMF travel bursaries.
- PhD Student, Norwich Medical School, University of East Anglia.
- Postdoctoral research associate within the Blood Cancers Research Group at the Centre for Cancer Research and Cell Biology, Queen's University Belfast
- Postdoctoral Training Fellow Myeloma Group. Division of Molecular Pathology, Institute of Cancer Research
- Specialist Cancer Pharmacist Oxford Cancer and Haematology Centre, Churchill Hospital, Oxford
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Review IMW 2017[ + ]
Thank you to the UKMF bursary winners for their IMW roundup.
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ASH 2016 Review[ + ]
Thank you to Dr Guy Pratt and Dr Ceri Bygrave for their review from ASH, San Diego 2016.
- ASH 2015 Review[ + ]
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IMW 2013 Review[ + ]
Sarah Essex was awarded a UKMF travel bursary to attend the 2013 IMW meeting in Kyoto. She has kindly reviewed this meeting in the attached document.
- ASH 2012 report by Aristeidi Chaidos[ + ]
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Report from ASH 2013[ + ]
Dr Lorenzo Melchor is a postdoctoral researcher and Dr Annamaria Brioli is a clinical research fellow at The Institute of Cancer Research and they were awarded a travel bursary to attend the ASH meeting in Atlanta in December 2013. They have written a brief report of their experience from this meeting.
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Report on the Multiple Myeloma & Related Malignancies Meeting, Bari, Nov 2011[ + ]
Meeting organisers, Professors Franco Dammacco and Angelo Vacca, assembled an impressive group of speakers for this enjoyable and informative meeting in the southern Italian Adriatic coastal city of Bari. Europe and the US were well represented by familiar key note speakers including Michel Attal, Herve Avet-Loiseau, Jean-Luc Harrouseau, Hartmut Goldschmidt, Michel Cavo, Antonio Palumbo, Pieter Sonneveld, David Roodman and Kenneth Anderson. Unfortunately, only the UK lacked senior representation from the UK myeloma community.
Michel Attal espoused once more the ‘new European emerging paradigm’ for intensive treatment comprising induction, autograft (+/- 2nd autograft), consolidation and maintenance. His other familiar proposition, strongly endorsed by Antonio Palumbo, was that achieving CR is becoming an increasingly feasible and desirable objective providing additional rationale for the use of the newer agents as first line induction therapy. He conceded that the optimal combination regimen for induction therapy was not yet established but did propose that Bortezomib and IMID based combinations may well prove superior. He also con
This meeting delivered a broad curriculum of current myeloma clinical practice and cutting edge new therapeutic strategies giving credence to Dr Anderson prediction that‘myeloma will become a chronic illness with complete responses in a significant fraction’ceded that it is currently unproven whether a second autograft is worthwhile, although in many cases it is clearly feasible. Furthermore, controversy continues as to whether the second autograft should be given early or late ie after relapse and re-induction. The UK Myeloma X trial will provide important evidence in this debate. Maintenance strategies have compared Bortezomib and lenalidomide although the latter agent appears the preferred option. Given these considerations, with the possible exception of the consolidation issue, the UK Myeloma XI Trial appears well designed and likely to address many of these issues.Kenneth Anderson summarised novel therapies and new targets under development at the Dana Faber Cancer Institute. Key approaches included immunotherapy approaches including elotuzumab, an IgG1 mab against CS1 target, expressed on MM cells and interestingly, up regulated by lenalidomide. His team are also targeting plasmacytoid dendritic cells (pDCs), key promoters of early myeloma cell colonization and expansion. Next generation proteosome inhibitors are in development including agents that target different proteosome components. Carfilzomib warranted a spec
ial mention due to the lack of peripheral neuropathy observed. Oral proteosome inhibitors are also under development and Dr Anderson concluded ‘I strongly believe the future of proteosome inhibitors is oral.’ Another exciting approach under development is to target protein homeostasis using aggresome inhibitors. The aggresome, is an intracellular organelle that forms when there is an accumulation of protein requiring disposal often seen if protein clearance is not fully effected by the proteosome. Hence inhibiting aggresome function is another method of inducing apoptosis. Furt
hermore, normal aggresome function is also mediated via HDAC activity providing a rationale for the use of HDAC inhibitors to disrupt this process.
Dr Andy Chantry
Senior Clinical Lecturer in Haematology/Honorary Consultant in Haematology
University of Sheffield/Sheffield Teaching Hospitals Foundation Trust