Executive committee


Click on the names below for UKMF officers’ biographies.

Officers


Professor Gordon Cook

Past Chair Read Biography

Professor  Gordon Cook

Professor of Haematology & Myeloma Studies, Consultant Haematologist

St James Institute of Oncology, Leeds Teaching Hospitals, Leeds, UK

I am a graduate of the University of Glasgow School of Medicine. I received my higher professional training in haematology in the West of Scotland. After completion of my PhD, I was appointed as a consultant Haematologist in the West of Scotland before moving to take up my present post based at Leeds Teaching Hospitals, in 2002.

I run a small peer-review grant-funded basic research group with areas of interests in transplantation and tumour immunology.

I am currently the President of the British Society of Blood & Marrow Transplantation. I represent the transplant society at the Government strategic and national commissioning level. I am a member of the NCRI Haematology-Oncology Clinical Studies Group. I am the secretary of the United Kingdom Myeloma Forum (UKMF) and have represented the interests of myeloma clinicians and patients in NICE reviews. I am a member of the NCRI Haem-Onc Myeloma sub-group and Principal Investigator for NCRI Myeloma X. In addition, I am a Board member of Myeloma UK and Medical Editor of Myeloma Today.


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Dr John Ashcroft

Chair Read Biography

John trained at Cambridge University qualifying in 1992. Following Junior Doctor training in East Anglia he moved to Leeds as a Specialist Registrar in Haematology where he completed both training and his PhD studying bone disease and how the underlying systems can be targeted to both prevent and reverse bone destruction.

John has been a Consultant Haematologist in Leeds and Mid Yorkshire NHS Trusts since 2005 and holds Honorary Senior Lecturer positions in the Universities of Leeds and York alongside his role as Mid Yorkshire Trust Research Director. His main research interests are multiple myeloma and bone disease. He is the UK Chief investigator for the ongoing bone study comparing Denusomab© and Zoledronic Acid, a member Trials management groups of other Uk studies including NCRI Myeloma X and the upcoming Myeloma XII trials and has contributed to the most recent UK Myeloma Guidelines


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Prof Guy Pratt

Secretary Read Biography

Dr Guy Pratt trained at Cambridge University qualifying in 1989. Following junior doctor training in London he specialized as a specialist registrar in Haematology in Liverpool and Leeds. In Leeds he completed an MD thesis looking at the genetic events involved in chromosomal translocations involving chromosome 14q32 in multiple myeloma patients.

Dr Pratt has been a Consultant Haematologist in Birmingham since 2001 as a clinical academic working in the School of Cancer Sciences in the University of Birmingham as a University Senior Lecturer and as an Honorary NHS Consultant at Heart of England NHS Trust. His main research interests are multiple myeloma and chronic lymphocytic leukaemia. His research interests are T cell immunity, genetic polymorphisms, investigating biomarkers including the serum free light chain and translational research currently leading on a trial of a parp inhibitor in CLL. He has developed a large number of collaborations nationally with a growing publication output and is currently lead for developing and promoting guidelines relating to plasma cell disorders.


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Dr Neil Rabin

Chair Elect Read Biography

Biography to follow


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Dr Rachel Hall

Treasurer Read Biography

Dr Rachel Hall MBBS, BSc, MRCP, FRCPath

Consultant Haematologist, The Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust

Dr Rachel Hall qualified at University College London in 1993. After working as a junior doctor in Haematology and Oncology at the Royal Bournemouth Hospital, she decided to pursue a career in Haematology. Rachel has worked in hospitals around the Wessex region training in Haematology and also worked for 2 years in Perth, Western Australia.

Rachel has been a Consultant Haematologist at The Royal Bournemouth Hospital since 2003 and has an interest in Myeloma, Lymphoma and Stem Cell Transplantation. She has set up specialist, multidisciplinary Myeloma clinics at Bournemouth and has a large clinical trial portfolio for Myeloma. Rachel is also involved with Myeloma UK and runs regular patient information days and is on the clinical trials network steering board.


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Elected Members


Dr Ceri Bygrave

Invited Welsh Regional Representative Read Biography

Dr Ceri Bygrave is a graduate of UWCM Cardiff and did her junior doctor training in South Wales and Australia. She then progressed as a haematology SpR in the Wales deanery which included 2 years research looking at the microenvironment in AML, supervised by Professor Alan Burnett and culminating in an MPhil. Myeloma has been her interest since undergraduate days and she was appointed as Myeloma Lead in UHW Cardiff in October 2014 and has helped set up the service and develop the clinical and research aspects of the department. She is also a member of the UKMRA and the MUK CTN.


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Dr Karthik Ramasamy

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Dr Karthik Ramasamy MBBS MRCP FRCPath PhD Consultant Haematologist

Dr Ramasamy completed Internal Medicine training in Nottingham and started his career in Haematology at Glasgow. He subsequently moved to Kings College London and completed a comprehensive haematology registrar training programme. During this time, he spent time in researching both clinical and laboratory aspects of myeloma. He studied the role of marrow microenvironment in supporting the survival and propagation of resistant myeloma. He specifically looked at modulation of c-Src signaling in myeloma cells and marrow microenvironment to sensitise resistant myeloma cells to further therapy. He moved to Oxford and has established a strong myeloma and other plasma cell dyscrasias clinical practice in collaboration with other centres in Thames Valley. He is the Lead Clinician for Myeloma and other plasma dyscrasias in Thames Valley Strategic Clinical Network. He is a Chief investigator of national myeloma studies and principal investigator of a number of myeloma trials involving first in man to established anti myeloma drugs. He is an executive member of UK Myeloma Forum and is an active

member of NCRI Myeloma studies Group. Dr Ramasamy has recently been appointed as Divisional Lead of Cancer Research across Thames Valley and South Midlands Research Network.

Clinical Interests:

Myeloma and other plasma cell Dyscrasias, stem cell transplantation, and Cancer clinical trials

Research (Clinical and Laboratory):

Epidemiology, pathophysiology and management of renal manifestations in plasma cell dyscrasias: Collaborators – Prof S Schey (KCL), Prof M Drayson (Univ of Birmingham), Dr C Winearls (Oxford Kidney Unit)

Pathophysiology and clinical management of myeloma induced bone disease: Collaborators – Dr K Javaid (NDORMS, Oxford), Dr C Edwards (NDORMS, Oxford)

Modulation of marrow environment to delay progression of myeloma: Collaborators- Dr Hal Drakesmith ( RDM, Oxford) , Dr Y Calle ( UOR) , Prof S Schey ( KCL) , Dr M Streetly ( KCL/ GSTT)

Recent Publications:

Double Refractory Myeloma: Analysis Of Clinical Outcomes and Medical- Resource Utilisation In a Single Centre. Gooding S, Lau I-Jun, Sheikh M, Roberts P, Wong J, Dickens E, Elvidge J, Lee D, Ramasamy K. Blood November 15, 2013 vol. 122 no. 21 1727

Lau I-Jun, Smith D, Aitchison R, Peniket A, Yong K, Rabin N, Ramasamy K. Bendamustine Combination Therapy in Patients Relapsed and/ or Refractory to Bortezomib and Lenalidomide. Clinical lymphoma myeloma and Leukaemia. Volume 13, Supplement 1, S189, April 2013

Bhole, M, Sadler R, Ramasamy K. Serum free light chains and its utility in monoclonal gammopathies. Annals of Clinical Biochemistry 2014 Jan 31.

Ramasamy K, Gandhi S, Ceesay M, Deppe S, Tenant- Flowers M, Marcus R, Schey S. Rituximab and Thalidomide combination for Castleman Disease. Br J Haematol 2012. Aug;158(3):421-3

Ramasamy K, Khatun H, Macpherson L, Caley MP, Sturge J, Mufti GJ, et al. Fluorescence based experimental model to evaluate the concomitant effect of drugs on the tumour microenvironment and cancer cells. Br J Haematol 2012. Jun;157(5):564-79

Schey S, Ramasamy K. Pomalidomide therapy for myeloma. Expert Opin

Investig Drugs 2011;20(5):691-700.

Ramasamy K, Mahmood S, Lim Z, Corderoy S, Devereux S, Mufti GJ, et al. Alemtuzumab based reduced-intensity conditioning allogeneic transplantation for myeloma and plasma cell leukemia – a single-institution experience. Clin Lymphoma Myeloma Leuk 2011;11(2):242-5.

Ramasamy K, Ladon D, Salisbury J, Ireland R. Mott cells in CD20-positive myeloma. Br J Haematol 2011;152(4):366.

Ramasamy K, Hazel B, Mahmood S, Corderoy S, Schey S. Bendamustine in combination with thalidomide and dexamethasone is an effective therapy for myeloma patients with end stage renal disease. Br J Haematol 2011;155(5):632-4.

SA Schey, GJ Morgan, Ramasamy K et al. The addition of cyclophosphamide to Lenalidomide and dexamethasone is well tolerated and safe and enhances response rate sin multiply relapsed/ refractory myeloma patients; A phase I/II study. Br J Haematol. 2010 Aug; 150(3):326-33.

Contact

  • Address:

Level 2, Cancer & Haematology Centre, Churchill Hospital,
Old Road,
Headington,

Oxford OX3 7LE Oxon, UK

Email: karthik.ramasamy@ouh.nhs.uk
◦ Confidential Email (Patient Details): kramasamy@nhs.net • Clinical Secretary – Mr Chris Capel

Telephone: 01865 235 886
Fax: 01865235260
Email: christopher.capel@ouh.nhs.uk

 


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Dr Martin Kaiser

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Martin Kaiser is a Clinician Scientist at The Institute of Cancer Research and Honorary Consultant Haematologist at The Royal Marsden Hospital London. He trained in medicine and haematology in Germany and joined the ICR and RMH in 2011. His research focuses on molecular biomarker discovery and target identification for stratified treatment in myeloma, with a focus on molecular high-risk disease. He also has a major interest in novel imaging approaches in myeloma. Martin leads a number of multi-centre clinical trials in myeloma, including one of the first stratified trials for high-risk myeloma. His laboratory performs central genetic and molecular analyses for a number of national clinical trials. He is Translational Lead for the UKMRA.


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Dr Matthew Jenner

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Dr Jenner is Haematology Clinical Lead at University Hospital Southampton NHS Foundation Trust with managerial responsibility for the clinical and laboratory service. He leads the myeloma team at UHS with direct responsibility for clinical management of myeloma and plasma cell disorders. The myeloma service provides care to patients in Southampton and South West Hampshire as well as tertiary referrals from other hospitals for specialist input including for clinical trials and transplantation. Dr Jenner is principal investigator of a portfolio of myeloma clinical trials encompassing all stages of the disease. He is the Co-Chief Investigator of the MUK ninestudies and is a member of the trial management groups for the Myeloma XI and XIV studies.

Dr Jenner was a member of the Guidelines Development Committee for the NICE Myeloma Guidelines published in February 2016. He is a core member of the NCRI/UKMRA Myeloma Clinical Trials subcommittee and chairs the British Society of Haematology Relapsed Myeloma Guidelines group. He is was elected as a member of the UK Myeloma Forum Executive committee in March 2018

June 2018


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Dr Jonathan Sive

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Dr Sive is a Consultant Haematologist at UCLH, where he is the Clinical Service Lead for a large local and referral population.

He qualified from Manchester University, before carrying out postgraduate haematology training in London. He was awarded a PhD from Cambridge University on the use of high-throughput genomics techniques in blood cancers. He returned to London and was appointed a consultant in 2016, moving to a myeloma-specific consultant post at UCLH in 2019.

Dr Sive is actively involved in myeloma research, as a member of the Trial Management Group for both the CARDAMON and Myeloma XV trials, and a member of the UK Myeloma Research Alliance. He is on the UKMF Guidelines committee, where he chairs the First Line Treatment sub-group.

He was elected to the UKMF Executive Committee in January 2020.


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Dr Shelly Lawson

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Department of Oncology & Metabolism, University of Sheffield

https://www.sheffield.ac.uk/oncology-metabolism/staff/lawson

Shelly graduated from the University of Sheffield with a BSc (Hons) in Molecular Biology in 1997 before completing a PhD at the University of Bristol focused on the use of DNA vaccines. In 2001 she did her first post-doc at the University of Oxford on biomaterials used in bone tissue engineering and on the binding affinities of bisphosphonates to bone. In 2005 she moved to the University of Sheffield to work on multiple myeloma, where she became a Research Fellow and then a Lecturer. Her work has focused on developing and utilizing several preclinical models of myeloma to design better treatment strategies. Her current research interests include the use of combination therapies to repair myeloma-induced bone disease and the development of novel bone-targeted anti-myeloma therapies.


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Co-opted Member


Dr Matthew Streetly

Advocacy Read Biography

Biography to follow


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Dr Simon Stern

Guidelines Chair Read Biography

Dr Simon Stern, Consultant Haematologist

Dr Stern graduated from St George’s Hospital Medical School, and his training in Haematology was at the Hammersmith, Charing Cross and Chelsea and Westminster Hospitals. He has been a Consultant Haematologist since 1999, initially at Surrey & Sussex Healthcare NHS Trust, and since 2010 at Epsom & St Helier University Hospitals NHS Trust. His main clinical interests centre on the haematological malignancies in general, and multiple myeloma in particular. He runs a weekly myeloma clinic, and has been the Principal Investigator for number of clinical trials in the disease.

He pursues his interest in clinical guidelines through his membership of UK Myeloma Forum Guidelines Group and the British Society for Haematology Haemato-oncology Task Force. He is also a member of the Myeloma UK Early Diagnosis Working Group.

 


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Dr Richard Soutar

Invited Regional Scottish Representative Read Biography

Richard is a consultant in Haematology and Transfusion Medicine, Greater Glasgow and Clyde Health Board / Scottish National Blood Transfusion Service. Honorary Clinical Senior Lecturer, University of Glasgow.

His principal interests are in  Multiple Myeloma and related plasma cell dyscrasias and hospital based Transfusion Medicine.


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Dr Sarah Lawless

Invited Regional Northern Ireland Representative Read Biography

Dr Sarah Lawless, MB BCH BAO Hons MRCP FRCPath

Dr Lawless is a Consultant Haematologist at Belfast City Hospital specialising in myeloma and lymphoma. Dr Lawless graduated with honours from Queen’s University Belfast and began her career in haematology at BCH in 2008.

She has as special interest in plasma cell disorders and is a member of the plasma cell subcommittee of the chronic malignancy working party group of The European Society for Blood and Marrow Transplantation (EBMT). She is currently primary investigator of two EBMT studies investigating plasma cell leukaemia and rare myeloma subtypes. She is actively  involved in clinical trials at BCH and is primary investigator on several myeloma trials at this site.


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Shelagh McKinlay

Patient/Charity Representative Read Biography

Shelagh McKinlay
Head of Patient Advocacy, Myeloma UK

As Head of Patient Advocacy at Myeloma UK, Shelagh is responsible for making sure the patient voice is heard and acted on by decision makers. She leads the patient advocacy team in helping to deliver access to the best new myeloma treatments, influencing cancer strategies and developing new ways of working with patients and their families. Shelagh has 25 years’ experience in high profile policy and public affairs roles, including Head of Corporate Affairs at one of Scotland’s largest primary care NHS Trusts and 10 years leading a committee clerking team at the Scottish Parliament. Shelagh has also worked as a writer, a policy consultant and as a campaigner in democratic engagement. She is an advisor to the Board of the Scottish Youth Parliament.”


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Dr Rakesh Popat

Science lead Read Biography

Consultant Haematologist and Honorary Clinical Senior Lecturer

Dr Rakesh Popat graduated from Guy’s and St Thomas’ Medical School, London and trained in haematology at St Bartholomew Hospital. During this time he completed a PhD thesis focusing on designing scientifically based treatment combinations for myeloma. This included pre-clinical work investigating novel combination treatments and developing them into early phase clinical studies. He was awarded a fellowship to visit the Dana Farber Cancer Institute in Boston, USA where he gained experience both in their drug-discovery laboratory and their clinical program.

In his current role he works within the large myeloma team at UCLH.  He leads the Phase 1 clinical trials program, bringing experimental myeloma treatments into the clinic.  In addition, he is the Industry lead to the UK Myeloma Research Alliance, the North Thames Clinical Research Network lead for Haematology and site lead for the Bloodwise Trials Acceleration Program.  He is the principle and national lead investigator for a number of clinical trials and collaborates to translational research at UCL Cancer Institute.


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Sarah Henshaw

Myeloma nurse lead Read Biography

Sarah Henshaw has been the Myeloma Clinical Nurse Specialist at the Nottingham Centre for Clinical Haematology for 12 years, and has been a Trustee of The Basil Skyers Myeloma Foundation since its inception until June 2018 until recently.

Sarah developed her interest in myeloma while she was working as a Staff Nurse in haematology at a local district general hospital. She also worked as a Staff Nurse and Clinical Nurse Educator at Nottingham University Hospital before becoming a Myeloma Clinical Nurse Specialist in April 2007. Recently she has become involved with an international working group of Myeloma CNS’s where she hopes to impact on the IMW nursing programme. In addition she is in the early phases of setting up a National Myeloma Nurse Network in conjunction with the UKMF, it is hoped this group will help standardise myeloma nursing care, share best practice, plug gaps in myeloma nurse related published work, develop protocols and develop nurse education.

She has set up and run four independent nurse-led clinics primarily managing patients’ pain and symptoms from their myeloma and associated treatments and MGUS.Her particular interests are quality of life for myeloma patients, pain management, late effects and the progression of new treatments. Following her Bachelor’s Degree in Health Care Studies, specialising in haemato-oncology, Sarah is an independent nurse prescriber who uses this skill extensively in her nurse led clinics and is also undertaking an MSc in Health and Social Care specialising in palliative and end of life care recently completing a module in Pain management.


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